Our Vision & Story

At CaladanAI, we believe biotech innovators should focus on breakthrough science, not on wrestling with spreadsheets and outdated financial models. We're building financial systems that reflect how decisions are actually made: tools that make uncertainty explicit, connect plans to reality, and support defensible decision-making as trials evolve.

Our Story

CaladanAI grew out of real client work. As Holly described recurring enrollment forecasting challenges from her biotech finance consulting, Jesse saw a consistent pattern: these weren't one-off problems, they were system failures that software could solve. Over time, those conversations became a shared conviction that the tools biotech teams relied on were fundamentally inadequate, and that a better approach could be built.

Over time, we both saw the same thing: this wasn't a spreadsheet problem. It was a systems problem. Biotech teams deserved better tools for the uncertainty they face every day. So we built them.

Why Choose Us

Built for Clinical Finance

Not adapted from generic finance tools. Every feature reflects how biotech teams actually plan, forecast, and report.

Uncertainty Made Explicit

Every projection shows what you know and what you don't. No hidden assumptions—just clear inputs, transparent logic, and honest ranges.

Defensible by Design

Full audit trails, version-controlled assumptions, and methodology documentation that satisfies finance teams and auditors alike.

Meet Our Founders

Holly Lujan

COO & CFO, Co-Founder

hlujan@caladan.ai

Holly is a finance and operations leader with 15 years of experience in biotech finance, supporting early-stage and emerging companies through high-stakes decisions. Her work spans financial modeling, clinical trial planning, cash forecasting, and board-level reporting, translating uncertainty into clear, defensible insight.

As COO and CFO of CaladanAI, she focuses on building systems that reflect how biotech companies actually operate, not how spreadsheets pretend they do. CaladanAI was created to replace fragile, manual models with a living financial intelligence platform—one that connects milestones, cash, and strategy in real time and evolves alongside the company.

Jesse Lujan

CEO, Co-Founder

jlujan@caladan.ai

Jesse leads product and engineering at CaladanAI, bringing a rare combination of scientific depth and product discipline. His career includes a decade in biotech R&D, developing clinical assays at Cellerant Therapeutics and EMD Millipore, followed by another decade leading product for enterprise SaaS companies.

As CEO, Jesse focuses on building technically rigorous, intuitive systems that meet the real demands of clinical development. CaladanAI emerged from his work translating complex enrollment and forecasting models into software, revealing how inadequately existing tools served teams operating under regulatory and scientific uncertainty.

"Together, Holly and Jesse founded CaladanAI to give biotech teams clarity they can trust—without oversimplification, and without losing sight of the realities behind the data."

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